Test Directory
Tissue Transglutaminase (tTG) Antibody, IgA Updated!
Print this pageThis test has recent updates .
Updated Test Information:
Additional Processing Details | |
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Last Updated | Mar 25, 2021, 9:15 pm |
Previous Value | |
New Published Value |
Stability | |
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Last Updated | Mar 25, 2021, 9:15 pm |
Previous Value | Stored at 22˚C: 8 hrs Stored at 2-8˚C: If assays are not completed within |
New Published Value | Stored at 22˚C: 8 hrs Stored at 2-8˚C: 1 week If assays are not completed within 1 week or the specimen is to be stored beyond 1 week, the serum/plasma should be frozen at or below -20˚C. |
Limitations | |
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Last Updated | Mar 25, 2021, 9:15 pm |
Previous Value | |
New Published Value |
Reference Range | |
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Last Updated | Mar 25, 2021, 9:15 pm |
Previous Value | |
New Published Value |
Test Description |
Tissue Transglutaminase (tTG) Antibody, IgA
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Synonym(s) |
tTG, Celiac |
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Test ID |
TTGA
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General Information |
Tissue transglutaminase (tTG) has been identified as the major autoantigen in celiac disease. IgA antibodies against tTG are highly disease specific serological markers for celiac disease and dermatitis herpetiformis. Patients with selective IgA deficiency may yield false negative tTG IgA results. Assay results should be used in conjunction with clinical findings and other serological tests. Antibodies directed against gliadin, its deamidated products, and tTG are dependent on the ingestion of gluten. For this reason, serology testing is best performed in patients on a gluten-containing diet. In children younger than 2 years, it is recommended to combine tissue transglutaminase (tTG) testing with deamidated gliadin (DGP) IgA and IgG. |
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Specimen Type |
Serum |
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Alternate Specimen Type |
Plasma (EDTA or Citrate) |
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Specimen Requirements |
Tiger |
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Additional Processing Details |
Heparin interferes with the measurement of tTG antibodies. |
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Stability |
Stored at 22˚C: 8 hrs |
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Unacceptable Specimen Conditions |
Li-Heparin, lipemic, hemolyzed or microbially contaminated samples. |
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Limitations |
In children younger than 2 years, it is recommended to combine tissue transglutaminase (tTG) testing with deamidated gliadin (DGP) IgA and IgG. |
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Methodology |
Fluorescent enzyme immunoassay (FEIA) |
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Estimated TAT |
2-5 days |
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Testing Schedule |
Monday-Saturday, alternating days |
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CPT Code(s) |
83516 |
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Minimum Sample Volume |
1 mL |
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Pediatric Min. Volume (if applicable) |
500 uL |
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Reference Range |
Negative < 7 U/mL |
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Performing Lab |
Incyte Diagnostics |
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LOINC Code(s) |
46128-5 |