Laboratory Services

Thalassemia and Hemoglobinopathy Evaluation, Blood and Serum

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Updated Test Information:

Test Description
Thalassemia and Hemoglobinopathy Evaluation, Blood and Serum
Synonym(s)

A2 Hemoglobin, Alpha Globin Variant, Alpha Thalassemia, Alpha-Thalassemia Evaluation, Barts Hemoglobin, Barts hydrops fetalis, Beta Globin Variant, Beta Thalassemia, E beta thalassemia, H Disease, Hb Barts, Hb H disease, HBA1, HBA2, HBB, HBG1, HBG2, Hemoglobin A2, Hemoglobin Cascade, Hemoglobin Electrophoresis, Hemoglobin, Electrophoresis Cascade Level 1, Hemoglobin H disease, Hemoglobin Molecular studies, Hemoglobin Variant, Hemoglobinopathy, HGB (Hemoglobin) Electrophoresis, HPFH, Hydrops fetalis, Isoelectric Focusing, Mass Spectrometry, Microcytosis, MLPA, S beta thalassemia, Sickle cell, Sickling Test, Thalassemia

Test ID
THEV1
General Information

Evaluation of microcytosis.
Extensive and economical diagnosis and classification of hemoglobinopathies or thalassemia including complex disorders.
Diagnosis of hereditary persistence of hemoglobin (HPFH).

Container Type

Lavender top (EDTA) and serum gel

Specimen Type

Serum AND whole blood (EDTA) are required

Specimen Requirements

Whole blood: 15ml EDTA (do not spin or aliquot)
Serum: 0.6mL

Specimen Collection / Processing Instructions

Serum:
1. Centrifuge and remove serum from red blood cells within 2 hours of draw.
2. Aliquot serum to submission container (plastic vial).


Whole blood: Send specimen in original tube. Do not aliquot

Stability

Refrigerated: 7 days
Room Temperature: not acceptable
Frozen: not acceptable

Unacceptable Specimen Conditions

Improper labeling, quantity not sufficient, improper collection container, gross hemolysis

Methodology

high-performance liquid chromatography (HPLC), capillary electrophoresis, immunoenzymatic assay, consultative interpretation

Estimated TAT

7 days. 14 days for abnormal samples

Testing Schedule

Monday - Saturday

Test Includes

Hemoglobinopathy Interpretation, Hb Variant, A2 and F Quantitation, HPLC Hb Variant, Ferritin

CPT Code(s)

83020-26-Hemoglobinopathy Interpretation
83020-Hb Variant, A2 and F Quantitation
83021-HPLC Hb Variant
82728-Ferritin
82664 (if appropriate)
83068 (if appropriate)
83789 (if appropriate)
88184 (if appropriate)

Minimum Sample Volume

Whole Blood: 2.5mL
Serum: 0.5mL

Reference Range

Definitive results and an interpretive report will be provided.

Reflex Conditions

See website: https://www.mayocliniclabs.com/test-catalog/Overview/608085

Performing Lab

Mayo Clinic