Test Directory

Apple, IgE, Serum

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Updated Test Information:

Test Description
Apple, IgE, Serum
Synonym(s)

Malus sylvestris; Malus x domestica

Test ID
APPL
General Information

Useful for:



  • Establishing a diagnosis of an allergy to apples

  • Defining the allergen responsible for eliciting signs and symptoms

  • Identifying allergens responsible for allergic disease and/or anaphylactic episode

  • Confirming sensitization prior to beginning immunotherapy

  • Investigating the specificity of allergic reactions to insect venom allergens, drugs, or chemical allergens

Specimen Type

Serum

Specimen Requirements

  • Preferred: Red Top

  • Acceptable: Serum Gel

Stability

  • Refrigerated (preferred): 14 days

  • Frozen: 90 days

Limitations

  • Testing for IgE antibodies is not useful in patients previously treated with immunotherapy to determine if residual clinical sensitivity exists, or in patients in whom the medical management does not depend upon identification of allergen specificity.

  • Some individuals with clinically insignificant sensitivity to allergens may have measurable levels of IgE antibodies in serum, and results must be interpreted in the clinical context.

  • False-positive results for IgE antibodies may occur in patients with markedly elevated serum IgE (>2,500 kU/L) due to nonspecific binding to allergen solid phases.

Methodology

Fluorescence Enzyme Immunoassay (FEIA)

Estimated TAT

1-3 days

Testing Schedule

Monday-Saturday

Retention

14 days

CPT Code(s)

86003

Additional Information
Minimum Sample Volume

  • For 1 allergen: 0.3 mL

  • For more than 1 allergen: (0.05 mL x number of allergens) + 0.25 mL deadspace

Reference Range
Class IgE kU/L Interpretation
0 < 0.35 Negative
1 0.35 - 0.69 Equivocal
2 0.70 - 3.49 Positive
3 3.50 - 17.4 Positive
4 17.5 - 49.9 Strongly positive
5 50.0 - 99.9 Strongly positive
6 ≥ 100 Strongly positive
Performing Lab

Mayo

LOINC Code(s)

6021-0