Laboratory Services
Anti Neutrophil Cytoplasm Panel
Print this pageUpdated Test Information:
| Test Description |
Anti Neutrophil Cytoplasm Panel
|
|
|---|---|---|
| Synonym(s) |
ANCAG, ANCA-Panel, Atypical ANCA, C ANCA, MPO, P ANCA, PR3, Vasculitis, Wegener's Antigen, UOW1551 |
|
| Test ID |
ANCAP
|
|
| General Information |
Anti-neutrophil cytoplasmic antibodies are detected by indirect immunofluorescence (IFA) using human neutrophil cellular preparations as substrate. The pattern and titer are reported on samples with positive results. The reported patterns are C-ANCA (cytoplasmic), P-ANCA (perinuclear), and atypical. Antibodies to human neutrophil cytoplasmic antigens (ANCA) are associated with autoimmune vasculitides such as Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA). The results of this assay should be used in conjunction with patient history, clinical findings and other test results for diagnosis. |
|
| Container Type |
6 mL Red Top or Gold SST Tube |
|
| Specimen Type |
Serum |
|
| Specimen Collection / Processing Instructions |
Separate serum and refrigerate |
|
| Minimum Sample Volume |
1mL serum |
|
| Limitations |
Strong anti-nuclear antibody (ANA) staining may resemble and/or obscure ANCA patterns. Antibodies to cytoskeletal fibers can mimic a C-ANCA pattern. |
|
| Department (code) |
Immunology |
|
| Methodology |
Indirect immunofluorescence (IFA) using INOVA ethanol fixed and formalin fixed neutrophils to detect autoantibodies. |
|
| Testing Schedule |
Monday - Friday |
|
| Test Includes |
ANCAIF ANCA, by IF |
|
| CPT Code(s) |
83520x2, 86036 |
|
| Performing Lab |
UW |
|
| LOINC Code(s) |
18719-5 |
