Test Directory

KRAS Mutation Analysis

Synonym(s):

KRAS, K-RAS, RAS

Application:

KRAS is part of the RAS gene family (KRAS, NRAS, and HRAS). The RAS proteins are involved in downstream growth factor receptor signaling which regulates cell growth, proliferation, and differentiation. KRAS mutations are found in a variety of cancers, including colon, rectal, lung, and thyroid cancers. KRAS gene mutation testing can aid in diagnosis, prognosis, and predicting patient outcome in response to targeted therapies.

Specimen Type:

Formalin-fixed, paraffin-embedded (FFPE) tissue block or 5 unstained slides at 5µM and one matching H&E slide

Required Information:

Complete the Incyte Diagnostics requisition with the patient's demographics, ordering physician, and a copy of the pathology report.

Specimen Stability:

Blocks and slides should be stored and shipped at room temperature.

Unacceptable Specimen:

Tumor tissue with less than 10% neoplastic cells present or broken slides.

Department:

Molecular Pathology

Method:

The KRAS Mutation Test is a real-time PCR assay designed for the qualitative detection of the mutations within exons 2, 3, and 4. Performance characteristics have been determined by Incyte Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration (FDA).

Turnaround:

15 business days from receipt

Performed:

Variable

Retention:

Extracted DNA is kept for a minimum of 60 days.

CPT Code:*

81275
81276

Test Code(s):

KRASPCR

*The listed CPT codes are for reference use only. Final coding is based on CPT guidelines and individual circumstances.

1-888-814-6277

©2019 Incyte Diagnostics. 13103 E Mansfield Ave, Spokane Valley, Washington 99216 USA. 509.892.2700. Website Design by Klündt | Hosmer. All rights reserved.