Test Directory

NRAS Mutation Analysis

Synonym(s):

NRAS, N-RAS, RAS

Application:

NRAS is part of the RAS gene family (KRAS, NRAS, and HRAS). The RAS proteins are involved in downstread growth factor receptor signaling which regulates cell growth, proliferation, and differentiation. NRAS mutations are found in a variety of cancers, including colon, rectal, small intestine, skin, and thyroid cancers. NRAS gene mutation testing can aid in diagnosis, prognosis, and predicting patient outcome in response to targeted therapies.

Specimen Type:

Formalin-fixed, paraffin-embedded (FFPE) tissue block or 5 unstained slides at 5µM and one matching H&E slide

Required Information:

Complete the Incyte Diagnostics requisition with the patient's demographics and relevant clinical history.

Specimen Stability:

Blocks and slides should be stored and shipped at room temperature

Unacceptable Specimen:

Tumor tissue with less than 10% neoplastic cells present or broken slides.

Department:

Molecular Pathology

Method:

The KRAS Mutation Test is a real-time PCR assay designed for the qualitative detection of the mutations within exons 2, 3, and 4. Performance characteristics have been determined by Incyte Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration (FDA).

Turnaround:

15 business days from receipt

Performed:

Variable

Retention:

Extracted DNA is kept for a minimum of 60 days.

CPT Code:*

81311

Test Code(s):

NRASPCR

*The listed CPT codes are for reference use only. Final coding is based on CPT guidelines and individual circumstances.

1-888-814-6277

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