Test Directory

Tacrolimus, Blood

Print this page

Updated Test Information:

Test Description
Tacrolimus, Blood
Synonym(s)
Tacrolimus
Test ID
TAKRO
General Information
Useful for:
Monitoring whole blood tacrolimus concentration during therapy, particularly in individuals coadministered CYP3A4 substrates, inhibitors, or inducers
Adjusting dose to optimize immunosuppression while minimizing toxicity
Evaluating patient compliance
Specimen Type
Whole Blood
Specimen Requirements
Lavender
Specimen Collection / Processing Instructions
Lavender - 1.Draw blood immediately before a schedule dose. 2.Do not centrifuge. 3.Send specimen in original tube. Additional Information: Therapeutic range applies to trough specimens drawn immediately prior to a.m. dose.
Stability
Refrigerated (preferred) 14 days
Ambient 14 days
Frozen 14 days
Unacceptable Specimen Conditions
Gross hemolysis OK
Gross lipemia OK
Gross icterus OK
Methodology
High-Performance Liquid Chromatography/Tandem Mass Spectrometry (HPLC-MS/MS)
Estimated TAT
1-2 days
Testing Schedule
Monday-Sunday
CPT Code(s)
80197
Minimum Sample Volume
1 mL
Reference Range
5.0-15.0 ng/mL (Trough)
Target steady-state trough concentrations vary depending on the type of transplant, concomitant
immunosuppression, clinical/institutional protocols, and time post-transplant. Results should be interpreted in
conjunction with this clinical information and any physical signs/symptoms of rejection/toxicity.
Performing Lab
Mayo
LOINC Code(s)
77348-1