Test Directory

Rapid Plasma Reagin Screen Response to Therapy, Serum

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Updated Test Information:

Test Description
Rapid Plasma Reagin Screen Response to Therapy, Serum
Synonym(s)

Rapid Plasma Reagin Test (RPR); Syphilis G; Syphilis Serology (RPR); Treponema pallidum (T. pallidum); Automated Reagin Test (ART)

Test ID
RPRRT
General Information

Useful for:



  • Determining the current disease status and evaluating response to therapy for syphilis

  • This test should not be used as a primary diagnostic approach for syphilis

    • To screen patients for an undiagnosed syphilis infection, order SYPHT (Syphilis Total Antibody with Reflex, Serum)



  • This test is not useful for testing spinal fluid specimens

  • This test is not intended for medical-legal use

  • This assay provides a rapid plasma reagin (RPR) screen and can be used to monitor response to therapy in patients treated for syphilis infection

  • If this test is positive, then the titer will be performed at an additional charge

Specimen Type

Serum

Specimen Requirements

  • Preferred: Serum Gel (SST)

  • Acceptable: Red Top

Stability

  • Refrigerated (preferred): 14 days

  • Frozen: 14 days

Unacceptable Specimen Conditions

  • Gross hemolysis

  • Gross lipemia

  • Heat-inactivated specimen

Limitations

Biological false-positive reactions with cardiolipin-type antigens have been reported in disease such as infectious mononucleosis, leprosy, malaria, lupus erythematosus, vaccinia, and viral pneumonia. Pregnancy, autoimmune diseases, and narcotic addictions may give false-positive results. Pinta, yaws, bejel, and other treponemal diseases may also produce false-positive results with this test

Methodology

RPRRT: Multiplex Flow Immunoassay
RRPRQ: Flocculation/Agglutination

Estimated TAT

1-4 days

Testing Schedule

Monday-Saturday

Retention

14 days

CPT Code(s)

0065U; 86593-Rapid Plasma Reagin Titer (if appropriate)

Additional Information
Minimum Sample Volume

0.4 mL

Reference Range

Nonreactive

Reflex Conditions

RRPRQ: RPR Titer

Performing Lab

Mayo

LOINC Code(s)

20507-0